Gastroprotective effects of Kangfuxin against water-immersion and restraint stress-induced gastric ulcer in rats: roles of antioxidation, anti-inflammation, and pro-survival
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چکیده
منابع مشابه
Gastroprotective effects of β3-adrenoceptor agonists on water immersion plus restraint stress-induced gastric ulcer in rats
Objective: To evaluate the gastroprotective effects of β 3 -adrenoceptor agonists CGP 12177A and SR 58611A, on water immersion plus restraint stress (WIRS)-induced gastric ulceration in rats. Material and Methods: Drugs were administered (5, 10 and 15 mg/kg, p.o. ) 30 min prior to the ulcerogenic procedure. Ulcer index and the score for intensity of intraluminal bleeding were determined. Gastri...
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Background: Escin was a natural mixture of triterpenoid saponin that was isolated from the seed of the horse chestnut. The previous study from our laboratory demonstrated that escin had a protective effect against indomethacin-induced gastric ulcers in mice. The aim of this study was to investigate the effect of escin on gastric mucosal lesions induced by water immersion and restraint stress (W...
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Introduction: The incidence rate of gastric erosions and ulcers in diabetic patients are higher due to failure of mucosal antioxidant defense and maintain enough blood flow. The present study evaluated the gastro-protective effect of sodium hydrosulfide (NaHS) against indomethacin-induced gastric lesions in diabetic rats. Methods: In order to test anti-ulcer activity of NaHS against indomet...
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Introduction: Anandamide (AEA) has shown a wide spectrum of pharmacological activities including the effects against the peptic ulcer, meanwhile, the poor solubility or short half-life may negatively affect the effectiveness of this valuable cannabinoid. Based on the superior properties of carbon nanotubes (CNTs) for controlled drug delivery, we aimed to prepare AEA-CNTs complex and evaluat...
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ژورنال
عنوان ژورنال: Pharmaceutical Biology
سال: 2019
ISSN: 1388-0209,1744-5116
DOI: 10.1080/13880209.2019.1682620